Hexahydro-1,4-diazepine → HCID 21891659, compound

HRID 720368Notes

Reaction equation

HRID 720368 reaction equation
Cl[CH2:2][C:3]1[S:4][C:5]2[CH:11]=[C:10]([O:12][CH3:13])[C:9]([O:14][CH3:15])=[C:8]([O:16][CH3:17])[C:6]=2[CH:7]=1.[NH:18]1[CH2:24][CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[CH3:17][O:16][C:8]1[C:6]2[CH:7]=[C:3]([CH2:2][N:18]3[CH2:24][CH2:23][CH2:22][N:21]([CH2:2][C:3]4[S:4][C:5]5[CH:11]=[C:10]([O:12][CH3:13])[C:9]([O:14][CH3:15])=[C:8]([O:16][CH3:17])[C:6]=5[CH:7]=4)[CH2:20][CH2:19]3)[S:4][C:5]=2[CH:11]=[C:10]([O:12][CH3:13])[C:9]=1[O:14][CH3:15]

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 21891619HCID 21891619, compound

Product 1

HCID 21891659HCID 21891659, compound

Procedure

2-Hydroxymethyl-4,5,6-trimethoxbenzothiophene (1.15 g) was treated in the same manner as in Preparation Example 4, and 2-chloromethyl-4,5,6-trimethoxy-benzothiophene thus obtained was immediately reacted with homopiperazine (226 mg) in the same manner as in Example 1 without isolating it to obtain the title compound as a free base.

Workup

  1. customthus obtained
  2. customwithout isolating it

Sources & evidence

ORD record
ord-620d06cd0753471088175b2f6c5819fd
Source dataset
uspto-grants-2006_11
Patent number
US07135473B2

Reaction notes

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