Acrylonitrile → HCID 10425502, compound

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Reaction Steps

The title compound was prepared from 1-(4-methyl-phenacyl)-quinolinium bromide (120 mg, 0.350 mmol), tetrapyridinecobalt(II) dichromate (229 mg, 0.376 mmol), sodium bicarbonate (74.7 mg, 0.889 mmol), acrylonitrile (120 μL, 1.82 mmol), and N,N-dimethylformamide (2.5 mL), similar to Example 1b, and yielded 30.6 mg (28%) as a yellow solid. 1H NMR (CDCl3): 8.05 (d, J=8.51 Hz, 1H), 7.98 (dd, J=6.60, 1.65 Hz, 2H), 7.84 (dd, J=7.83, 1.51 Hz, 1H), 7.71 (d, J=9.34 Hz, 1H), 7.67 (d, J=9.07 Hz, 1H), 7.60 (ddd, J=8.24, 7.08, 1.58 Hz, 1H), 7.52 (td, J=7.49, 1.19 Hz, 1H), 7.40 (s, 1H), 7.37 (d, J=7.97 Hz, 2H), 2.50 (s, 3H).

Provenance & Evidence