N,N-Dimethyl-1,3-propanediamine → 3-Cyano-1-[4-(3-dimethylamino-propylamino)-benzoyl]-pyrrolo[1,2-a]quinoline

Participants

Reaction Steps

The title compound was prepared as described for Example 21, using 3-cyano-(4-fluoro-benzoyl)-pyrrolo[1,2-a]quinoline (65 mg, 0.206 mmol) and N1,N1-dimethyl-propane-1,3-diamine (200 mg, 1.96 mmol) and yielded 68 mg (83%). 1H NMR (CDCl3): 7.98 (m, 2H), 7.81 (dd, J=7.5, 1.8 Hz, 1H), 7.55 (m, 4H), 7.31 (s, 1H), 6.63 (d, J=9.0 Hz, 2H), 5.78 (s, broad, 1H), 3.34 (m, 2H), 2.51 (t, J=6.3 Hz, 2H), 2.31 (s, 6H), 1.85 (m, 2H).

Provenance & Evidence