Potassium Carbonate → HCID 21892140, compound

Participants

Reaction Steps

A mixture of 3-cyano-1-(3-hydroxy-benzoyl)-pyrrolo[1,2-a]quinoline (31.2 mg, 0.1 mmol), 4-(2-chloroethyl)morpholine hydrochloride (37.2 mg, 0.2 mmol), potassium carbonate (165 mg, 1 mmol) in acetone (5 mL) was refluxed for 4 h. It was evaporated to dryness and the residue was purified by column chromatography (EtOAc) to give 16 mg (37%) of the title compound. 1H NMR (CDCl3): 8.06 (d, J=8.7 Hz, 1H), 7.86–7.83 (m, 1H), 7.75–7.43 (m, 8H), 7.26–7.20 (m, 1H), 4.20 (t, J=5.60 Hz, 2H), 3.74 (t, J=4.80 Hz, 4H), 2.85 (t, J=5.40 Hz, 2H), 2.60 (t, (t, J=4.50 Hz, 4H).

Provenance & Evidence