HCID 10425502, compound → HCID 21892176, compound

HRID 720429Notes

Reaction equation

HRID 720429 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:16](=[O:25])[C:17]2[CH:22]=[CH:21][C:20]([CH2:23]Br)=[CH:19][CH:18]=2)[N:6]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8][C:7]=12)#[N:2].C(C1C=[C:30](C(=O)C2C=CC(C)=CC=2)[N:31]2C3C(=CC=CC=3)C=C[C:32]=12)#N>>[C:1]([C:3]1[CH:4]=[C:5]([C:16](=[O:25])[C:17]2[CH:22]=[CH:21][C:20]([CH2:23][N:31]([CH3:32])[CH3:30])=[CH:19][CH:18]=2)[N:6]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8][C:7]=12)#[N:2]

Participants

3

Reactant 2

HCID 10425502HCID 10425502, compoundHCID 21892160HCID 21892160, compound

Product 1

HCID 21892176HCID 21892176, compound

Procedure

3-Cyano-1-[4-(bromomethyl)benzoyl]-pyrrolo[1,2-a]quinoline. The title compound was prepared similar as Example 53a, using 3-cyano-1-(4-methylbenzoyl)-pyrrolo[1,2-a]quinoline to yield 230 mg (68%). 1H NMR (CDCl3): 8.09–8.10 (m, 3H), 7.87–7.52 (m, 7H), 7.43 (s, 1H), 4.58 (s, 2H).

Workup

  1. customto yield 230 mg (68%)

Sources & evidence

ORD record
ord-078b038058404a57a69f28d63de73f4b
Source dataset
uspto-grants-2006_11
Patent number
US07135480B2

Reaction notes

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