Potassium Iodide → HCID 21892157, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-benzoyl-3-cyano-6-hydroxy-pyrrolo[1,2-α]quinoline (31 mg, 0.10 mmol), N-(2-chloro-ethyl)-morpholine hydrochloride (25 mg, 0.13 mmol), potassium carbonate (138 mg, 1.0 mmol) and potassium iodide (18 mg, 0.11 mmol) in anhydrous acetone (10 mL) was heated in 60° C. oil bath for 2.5 days. The solvent was evaporated, and the residue was stirred with EtOAc (25 mL) and filtered. The EtOAc filtrate was evaporated and the crude product was purified by chromatography (SiO2, EtOAc/hexanes 50 to 100%) to give a light yellow solid (18 mg, 42%): 1H NMR (CDCl3): 8.21 (d, J=9.6, Hz, 1H), 8.08 (m, 1H), 8.05 (m, 1H), 7.71–7.47 (m, 6H), 7.42 (s, 1H), 6.94 (d, J=7.2 Hz, 1H), 4.33 (t, J=6.0 Hz, 2H), 3.76 (t, J=4.8 Hz, 4H), 2.97 (t, J=6.0 Hz, 2H), 2.65 (t, J=4.5 Hz, 4H).

Provenance & Evidence