Potassium Carbonate → HCID 10405905, compound

Participants

Reaction Steps

Part B: Acetic acid 2-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-ethyl ester (1.26 g, 3.17 mmol) was dissolved in methanol (100 mL) and water (5 mL). Potassium carbonate (1.31 g, 9.52 mmol) was added, and the reaction was stirred overnight at rt. The reaction was concentrated, quenched with water (250 mL), extracted with ethyl acetate (3×250 mL), washed with brine (1×100 mL), dried over MgSO4, concentrated, and purified by flash chromatography with 0–100% ethyl acetate/hexanes gradient as eluent to afford the title compound (1.01 g, 90%): 1HNMR(CDCl3) δ 7.45 (d, j=9.2 Hz, 2H), 6.96 (d, j=8.7 Hz, 2H), 3.84 (s, 3H), 3.82–3.77 (m, 4H), 3.66 (t, j=5.1 Hz, 2H), 3.03 (t, j=6.8 Hz, 2H) ppm; Mass Spec 356.3(M+H)+.

Provenance & Evidence