Ammonium Chloride → HCID 86591293, compound

Participants

Reaction Steps

Azabicycles of general formula (43), (44), (45), (46) and (47), wherein R is aryl or heterocycle, R′ is alkyl and R1 is as defined in formula (I), may be prepared as described in Scheme 12. Benzyl (cis)-6,6-dichloro-5-oxohexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate, prepared as described in Tetrahedron Lett. (1997) 38(11), 1869–1872, may be treated with zinc dust and ammonium chloride to provide benzyl (cis)-5-oxohexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate. Benzyl (cis)-5-oxohexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate may be processed as described in Schemes 2–8 to provide azabicycles of general formula (43), (44), (45), (46) and (47).

Provenance & Evidence