HCID 58739371, compound → HCID 86591296, compound

Participants

Reaction Steps

Azabicycles of general formula (98), (99), (100) and (101), wherein R is aryl or heterocycle, R′ is alkyl and R1 is as defined in formula (I), may be prepared as described in Scheme 24. Benzyl (trans)-5-oxooctahydro-2H-cyclopenta[c]pyridine-2-carboxylate, prepared as described in Eur. J. Med. Chem. (1991) 26, 889–906, may be epimerized with a base such as, but not limited to, triethylamine to provide benzyl (cis)-5-oxooctahydro-2H-cyclopenta[c]pyridine-2-carboxylate. Benzyl (cis)-5-oxooctahydro-2H-cyclopenta[c]pyridine-2-carboxylate may be processed as described in Schemes 2–8 to provide azabicycles of general formula (98), (99), (100) and (101).

Provenance & Evidence