HCID 58739335, compound → HCID 86591297, compound

Participants

Reaction Steps

Azabicycles of general formula (114), (115), (116) and (117), wherein R is aryl or heterocycle, R′ is alkyl and R1 is as defined in formula (I), may be prepared as described in Scheme 27. Benzyl (trans)-7-oxooctahydro-2H-cyclopenta[c]pyridine-2-carboxylate, prepared as described in Eur. J. Med. Chem. (1991) 26, 889–906, may be epimerized with a base such as, but not limited to, triethylamine to provide benzyl (cis)-7-oxooctahydro-2H-cyclopenta[c]pyridine-2-carboxylate. Benzyl (cis)-7-oxooctahydro-2H-cyclopenta[c]pyridine-2-carboxylate may be processed as described in Schemes 2–8 to provide azabicycles of general formula (114), (115), (116) and (117).

Provenance & Evidence