Ammonium Chloride → HCID 21892325, compound

Participants

Reaction Steps

Benzyl 6,6-dichloro-5-oxohexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate (3.87 g, 11.8 mmol), prepared as described in Tetrahedron Lett. (1997), 38, 1869–1872, in MeOH (60 mL) at 0° C. was treated with solid ammonium chloride (6.32 g, 118 mmol) followed by zinc duct (Aldrich; 3.09 g, 47.2 mmol). After stirring at room temperature for 1 hour, the reaction mixture was filtered and the filtrate concentrated under reduced pressure. The residue was purified by chromatography (SiO2, 40% EtOAc/hexanes) to provide 2.57 g (84%) of the title compound. MS (DCI/NH3) m/z 260 (M+H)+.

Provenance & Evidence