HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Ethyl-5-hydroxy-1,4,5,8-tetrahydrooxepino[3,4-c]pyridine-3,9-dione → 5,12-diethyl-9-fluoro-5-hydroxy-10-methoxy-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Ethyl-5-hydroxy-1,4,5,8-tetrahydrooxepino[3,4-c]pyridine-3,9-dione | HCID 10537047 | — |
| Reactant | HCID 21891951 | HCID 21891951 | — |
| Product | 5,12-diethyl-9-fluoro-5-hydroxy-10-methoxy-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione | HCID 21891894 | — |
Reaction Steps
(2-chloro-4-ethyl-7-fluoro-6-methoxy-3-quinolinyl)methanol is coupled with compound (M) as described in Stage 11.j. of Example 11. The resultant coupled product is cyclized according to the procedure described in Stage 11.k. A yellow solid is obtained, m.p.>275° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07135478B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-c94e3d94cfc241a7968c661b4b5ffa0b |
| Source note | uspto-grants-2006_11 |