Butanal → (5R)-5-ethyl-9-fluoro-5-hydroxy-12-propyl-4,5,13,1 5-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione

Participants

Role	Name	HCID	Charge
Reactant	Butanal	HCID 261	—
Reactant	(5R)-5-ethyl-9-fluoro-5-hydroxy-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione	HCID 9929755	—
Product	(5R)-5-ethyl-9-fluoro-5-hydroxy-12-propyl-4,5,13,1 5-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione	HCID 69591043	—

The product of Example 84 is treated with butyraldehyde according to a procedure similar to Stage 95e in order to produce the expected solid.