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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 720516Generated: October 26, 2026

4,4,4-Trifluorobutanal → (5R)-5-ethyl-9-fluoro-5-hydroxy-12-(3,3,3-trifluoropropyl)-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino [1,2-b]quinoline-3,15-dione

https://huagongshe.com/reaction/720516

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,4,4-TrifluorobutanalHCID 2777083—
Reactant(5R)-5-ethyl-9-fluoro-5-hydroxy-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dioneHCID 9929755—
Product(5R)-5-ethyl-9-fluoro-5-hydroxy-12-(3,3,3-trifluoropropyl)-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino [1,2-b]quinoline-3,15-dioneHCID 69591349—

Reaction Steps

The product of Example 84 is treated with 4,4,4-trifluorobutyraldehyde according to a procedure similar to Stage 95e in order to produce the expected solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07135478B2
Source datasetuspto-grants-2006_11
ORD IDord-9e7cb85026334ede8ad536706d17a12a
Source noteuspto-grants-2006_11