Methanol → HCID 9841775, compound

HRID 720527Notes

Reaction equation

HRID 720527 reaction equation
Cl.[CH3:2][C:3]([NH:15][CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([O:25]CC2C=CC=CC=2)=[C:21]([O:33]CC2C=CC=CC=2)[C:20]=1[CH3:41])=[O:18])([CH3:14])[CH2:4][C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7](O)[C:6]=1[CH3:13].C[OH:43]>[Pd]>[CH3:14][C:3]([NH:15][CH2:16][CH:17]([C:19]1[C:20]([CH3:41])=[C:21]([OH:33])[C:22]([OH:25])=[CH:23][CH:24]=1)[OH:18])([CH3:2])[CH2:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([OH:43])=[CH:7][C:6]=1[CH3:13]

Participants

4

Reactant 2

HCID 887MethanolHCID 69598140HCID 69598140, compound

Product 1

HCID 9841775HCID 9841775, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

7 g of 2-[1,1-dimethyl-2-(2,6-dimethylhydroxyphenyl)ethylamino]-1-(3,4-dibenzyloxy-2-methylphenyl)ethanone hydrochloride in 125 mL of methanol is hydrogenated using 2 g of palladium on charcoal (5%). After separation of the catalyst, the solvent is distilled off. The solid that crystallizes out is stirred into acetonitrile, suction filtered, and washed. Yield: 3.5 g of hydrochloride; melting point: 182° C.–183° C. (decomposition).

Workup

  1. customAfter separation of the catalyst
  2. distillationthe solvent is distilled off
  3. customThe solid that crystallizes out
  4. filtrationfiltered
  5. washwashed

Sources & evidence

ORD record
ord-3cfde785ca034e8dbb4fb3899807b548
Source dataset
uspto-grants-2006_11
Patent number
US07135500B2

Reaction notes

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