1-(Bromomethyl)-2,4-difluorobenzene → HCID 10064279, compound

Participants

Reaction Steps

2-Benzyloxy-6-(2,4-difluoro-benzyl)-1,6-dihydrodipyrrolo[3,2-d: 3′,4′-b]pyridin-3(2H)-one. The title compound was prepared by alkylation of 2-benzyloxy-1,6-dihydrodipyrrolo[3,2-d:3′,4′-b]pyridin-3(2H-one with 2,4-difluorobenzyl bromide in a manner similar to step (a) of example 1. 1H NMR (CD3OD) δ; 8.91 (s, 1H), 7.75 (d, 1H, J=3.0 Hz), 7.51–7.54 (m, 2H), 7.38–7.40 (m, 3H), 7.27–7.29 (m, 1H), 7.02–7.05 (m, 1H), 6.93–7.01 (m, 1H), 6.71 (d, 1H, J=3.0 Hz), 5.64 (s, 2H), 5.18 (s, 2H), 4.65 (s, 2H). LCMS (API-ES, M+H+): 406.1.

Provenance & Evidence