HRID72059

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC1=C[C@]23CCCN2CCc2cc4c(cc2[C@@H]3[C@@H]1O)OCO4

HCID65305

未命名化合物

结构：COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@@H]1C(OC)=C[C@]23CCCN2CCc2cc4c(cc2[C@H]13)OCO4

HCID285033

未命名化合物

PRODUCTS

生成物

HCID285033

未命名化合物

HCID56841046

未命名化合物

收率 0.05%

PROCEDURE

实验过程

Crude homoharringtonine, prepared according to Example 25 from a partially racemized natural cephalotaxine and purified by chromatography and crystallisation according to the method A of Example 27, gave an homoharringtonine showing a non natural enantiomeric epi-homoharringtonine content less than 0.05%.

WORKUP

后处理

custompurified by chromatography and crystallisation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9a8867e83df149a583f3a1bd4e6cde07
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: USRE045128E1
来源说明: uspto-grants-2014_09

反应 SMILES

[CH3:1][C:2]([OH:39])([CH2:4][CH2:5][CH2:6][C@:7]([OH:38])([C:13]([O:15][C@@H:16]1[C:32]([O:33][CH3:34])=[CH:31][C@:27]23[CH2:28][CH2:29][CH2:30][N:26]2[CH2:25][CH2:24][C:23]2[CH:22]=[C:21]4[O:35][CH2:36][O:37][C:20]4=[CH:19][C:18]=2[C@H:17]13)=[O:14])[CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH3:3].COC1[C@@H](O)[C@@H]2[C@@]3(N(CCC4C=C5OCOC5=CC=42)CCC3)C=1>>[CH3:3][C:2]([OH:39])([CH2:4][CH2:5][CH2:6][C@:7]([OH:38])([C:13]([O:15][C@@H:16]1[C:32]([O:33][CH3:34])=[CH:31][C@:27]23[CH2:28][CH2:29][CH2:30][N:26]2[CH2:25][CH2:24][C:23]2[CH:22]=[C:21]4[O:35][CH2:36][O:37][C:20]4=[CH:19][C:18]=2[C@H:17]13)=[O:14])[CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH3:1].[CH3:3][C:2]([OH:39])([CH2:4][CH2:5][CH2:6][C@@:7]([OH:38])([C:13]([O:15][C@@H:16]1[C:32]([O:33][CH3:34])=[CH:31][C@:27]23[CH2:28][CH2:29][CH2:30][N:26]2[CH2:25][CH2:24][C:23]2[C:18](=[CH:19][C:20]4[O:37][CH2:36][O:35][C:21]=4[CH:22]=2)[C@H:17]13)=[O:14])[CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH3:1]