3-(Trifluoromethyl)benzenesulfonyl chloride → HCID 21893405, compound

HRID 720593Notes

Reaction equation

HRID 720593 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]([CH3:25])[CH2:17][NH:18][S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[F:26][C:27]([F:39])([F:38])[C:28]1[CH:29]=[C:30]([S:34](Cl)(=[O:36])=[O:35])[CH:31]=[CH:32][CH:33]=1>>[F:39][C:27]([F:26])([F:38])[C:28]1[CH:29]=[C:30]([S:34]([NH:1][CH2:2][CH2:3][C:4]2[CH:5]=[CH:6][C:7]([C:10]3[CH:15]=[CH:14][C:13]([CH:16]([CH3:25])[CH2:17][NH:18][S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])=[CH:12][CH:11]=3)=[CH:8][CH:9]=2)(=[O:35])=[O:36])[CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chlorideHCID 21893565HCID 21893565, compound

Product 1

HCID 21893405HCID 21893405, compound

Procedure

The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of material from Example 50 and 19 mg (0.11 mmol) 3-trifluoromethyl-benzenesulfonyl chloride. NMR was consistent with the proposed compound.

Sources & evidence

ORD record
ord-c71f92df12a14404904ddb53c5a01c39
Source dataset
uspto-grants-2006_11
Patent number
US07135487B2

Reaction notes

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