2-Thiophenecarbonyl chloride → HCID 69594900, compound

HRID 720598Notes

Reaction equation

HRID 720598 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]([CH3:25])[CH2:17][NH:18][S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[S:26]1[CH:30]=[CH:29][CH:28]=[C:27]1[C:31](Cl)=[O:32]>>[S:26]1[CH:30]=[CH:29][CH:28]=[C:27]1[C:31]([NH:1][CH2:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]([CH3:25])[CH2:17][NH:18][S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1)=[O:32]

Participants

3

Reactant 2

HCID 789282-Thiophenecarbonyl chlorideHCID 21893565HCID 21893565, compound

Product 1

HCID 69594900HCID 69594900, compound

Procedure

The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of material from Example 50 and 11 μL (0.11 mmol) 2-thiophenecarbonyl chloride. NMR was consistent with the proposed compound.

Sources & evidence

ORD record
ord-04c9dd79caf24301bdaf50fdf5521b43
Source dataset
uspto-grants-2006_11
Patent number
US07135487B2

Reaction notes

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