反应详情

Water for injection was added to 2000 g titer equivalent amount of novel non-aseptic carbapenem hydrochloride derivative to give 20 kg dispersion. This dispersion was stirred and dissolved under ice-cooling to prepare a charge solution. Thereafter, the solution was aseptically filtered through a 0.2 μm membrane filter (MCGL20S03, 0.2 μm, Millipore) and fed to a crystallization tank (equipped with a jacket). Then, the crystallization tank was stirred by bubbling with nitrogen at 0 to 15° C., and 25 L isopropyl alcohol was aseptically added thereto. After crystallization, 55 L isopropyl alcohol was added aseptically added thereto over 1 hour or so. After aging for a predetermined time, the precipitated crystals were collected aseptically by filtration. The crystals were washed with isopropyl alcohol and acetone, and dried in a nitrogen stream with regulated humidity (20 to 40 RH %) for 10 hours or more, to give novel aseptic carbapenem hydrochloride trihydrate crystals.

1. customto give 20 kg dispersion
2. dissolutiondissolved under ice-
3. temperaturecooling
4. customto prepare a charge solution
5. filtrationThereafter, the solution was aseptically filtered through a 0.2 μm membrane
6. filtrationfilter (MCGL20S03, 0.2 μm, Millipore)
7. customequipped with a jacket)
8. stirringThen, the crystallization tank was stirred
9. customby bubbling with nitrogen at 0 to 15° C.
10. addition25 L isopropyl alcohol was aseptically added
11. customAfter crystallization, 55 L isopropyl alcohol
12. additionwas added aseptically
13. additionadded
14. filtrationthe precipitated crystals were collected aseptically by filtration
15. washThe crystals were washed with isopropyl alcohol and acetone
16. customdried in a nitrogen stream with regulated humidity (20 to 40 RH %) for 10 hours or more