HCID 14969713, compound → HCID 14969720, compound

HRID 720607Notes

Reaction equation

HRID 720607 reaction equation
C(N1C(=O)C(N)=C(N)N(CCCC)C1=O)C=C.[NH2:18][C:19]1[NH:24][C:23](=[O:25])[N:22]([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21](=[O:33])[C:20]=1[N:34]=O.C(N1C(=O)C(N=O)=C(N)N(CCCC)C1=O)C=C>>[CH2:26]([N:22]1[C:21](=[O:33])[C:20]([NH2:34])=[C:19]([NH2:18])[NH:24][C:23]1=[O:25])[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

4

Reactant 3

HCID 14969713HCID 14969713, compoundHCID 21891776HCID 21891776, compoundHCID 21891787HCID 21891787, compound

Product 1

HCID 14969720HCID 14969720, compound

Conditions

Temperature
0 °C

Procedure

This compound was prepared by a method similar to that of Müller et al. as described in Synthesis 1995, 1295. The method used was similar to that used in scheme 1 for the preparation of 3-allyl-5,6-diamino-1-butyl-1H-pyrimidine-2,4-dione except that 6-amino-3-benzyl-5-nitroso-1H-pyrimidine-2,4-dione was used as the substrate for the reaction in place of 3-allyl-6-amino-1-butyl-5-nitroso-1H-pyrimidine-2,4-dione and concentration was continued only until a solid precipitate was observed. This mixture was then cooled overnight at 0° C. and the solids isolated by filtration under an atmosphere of nitrogen to give 3-benzyl-5,6-diamino-1H-pyrimidine-2,4-dione.

Workup

  1. customThis compound was prepared by a method similar to that of Müller et al.
  2. customas described in Synthesis 1995, 1295
  3. customthe solids isolated by filtration under an atmosphere of nitrogen

Sources & evidence

ORD record
ord-5d35ddaf22f94597839f305d1a8f0884
Source dataset
uspto-grants-2006_11
Patent number
US07135475B2

Reaction notes

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