Phosgene → HCID 10324797, compound

HRID 720618Notes

Reaction equation

HRID 720618 reaction equation
[F:1][C:2]1[CH:37]=[CH:36][CH:35]=[CH:34][C:3]=1[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[NH:11][C:10]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:25])[CH3:24])=[CH:18][CH:17]=3)=[N:9][C:8]=2[N:7]([CH2:26][CH2:27][CH2:28][C:29]([NH:31][NH2:32])=[O:30])[C:6]1=[O:33].[C:38](Cl)(Cl)=[O:39]>>[F:1][C:2]1[CH:37]=[CH:36][CH:35]=[CH:34][C:3]=1[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[NH:11][C:10]([CH2:15][C:16]3[CH:17]=[CH:18][C:19]([NH:22][C:23](=[O:25])[CH3:24])=[CH:20][CH:21]=3)=[N:9][C:8]=2[N:7]([CH2:26][CH2:27][CH2:28][C:29]2[O:30][C:38](=[O:39])[NH:32][N:31]=2)[C:6]1=[O:33]

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 10051956HCID 10051956, compound

Product 1

HCID 10324797HCID 10324797, compound

Procedure

Prepared by reacting N-{4-[1-(2-fluorobenzyl)-3-(3-hydrazinocarbonyl-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl]-phenyl}-acetamide with phosgene according to the general procedure of Kramer et al. as described in J. Heterocyclic Chem. 1994,31, 1439. MS, m/z(M+H)=533.1821.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-39879c78dd8e429b891d4cadd1ffa028
Source dataset
uspto-grants-2006_11
Patent number
US07135475B2

Reaction notes

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