Hydrochloric Acid → HCID 21891802, compound

Participants

Reaction Steps

[4-(1-Benzyl-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl)-phenyl]-carbamic acid tert-butyl ester (303 mg) was suspended in p-dioxane (3 mL) and 4M HCl in p-dioxane (Aldrich, 5 mL) added. After 17 h the reaction mixture was poured into water and the mixture cautiously neutralized with saturated aqueous sodium bicarbonate. Brine was added to the mixture which was then thoroughly extracted with dichloromethane. The combined organic extracts were dried (sodium sulfate) and concentrated in vacuo to give the desired product as an orange solid (241 mg).

Provenance & Evidence