反应详情

This compound was prepared by a method similar to that described in example 79 except that commercially available 6-methylnicotinic acid was used in place of N-acetyl-6-amino-2-pyridine carboxylic acid, the reaction was performed using 0.54 equivalents of 3-cyclopropylmethyl-8-[4-(methylamino)-benzyl]-1-(2-fluorobenzyl)-3,7-dihydropurine-2,6-dione and 1.2 equivalents of triethylamine were added as the final reagent to the reaction mixture. The product was purified by chromatography using silica gel eluted with 95:5 chloroform/methanol followed by crystallization from acetonitrile. MS, m/z(M+)=553.2365.

1. customThis compound was prepared by a method similar to
2. customThe product was purified by chromatography
3. washeluted with 95:5 chloroform/methanol
4. customfollowed by crystallization from acetonitrile