6-Cyanopyridine-3-carboxylic acid → HCID 58739242, compound

Participants

Reaction Steps

This compound was prepared by a method similar to that described in example 79 except that 6-cyanonicotinic acid (Lancaster) was used in place of N-acetyl-6-amino-2-pyridine carboxylic acid, the reaction was performed using 0.66 equivalents of 3-cyclopropylmethyl-8-[4-(methylamino)-benzyl]-1-(2-fluorobenzyl)-3,7-dihydropurine-2,6-dione and 0.68 equivalents of 4-dimethylaminopyridine was added as the final reagent to the reaction mixture. The product was purified by chromatography using silica gel eluted with 5:95 hexanes/ethyl acetate followed by crystallization from acetonitrile. MS, m/z(M+)=564.2161.

Provenance & Evidence