Sodium Hydroxide → HCID 21891739, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-acetylamino-2-methyl-thiophene-3-carboxylic acid methyl ester (250 mg, 1.17 mmol) in methanol (4.0 mL) at 25° C. was treated with a 1N aqueous sodium hydroxide solution (3.5 mL, 3.51 mmol). The reaction was stirred at 25° C. for 28 h. At this time, the reaction was concentrated in vacuo, diluted with water (15 mL), and then acidified to pH=2 by the addition of a 1N aqueous hydrochloric acid solution. The resulting slurry was cooled to 0° C. The solid was collected by filtration, washed with water, and the dried in vacuo to afford 4-acetylamino-2-methyl-thiophene-3-carboxylic acid (212 mg, 90.9%) as a tan solid: LR-MS for C8H9NO3 (M−H)+ at m/z=198.

Provenance & Evidence