Sodium Hydroxide → HCID 21891837, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-carbamoyl-thiophene-2-carboxylic acid methyl ester (125 mg, 0.67 mmol) in methanol (2.0 mL) at 25° C. was treated with a 1N aqueous sodium hydroxide solution (2.0 mL, 2.02 mmol). The reaction was stirred at 25° C. for 18 h. At this time, the reaction was concentrated in vacuo. The residue was diluted with water (10 mL) and then acidified to pH=2 with a 1N aqueous hydrochloric acid solution. The resulting slurry was cooled to 0° C. The solids were collected by filtration, washed with water, and dried in vacuo to afford 3-carbamoyl-thiophene-2-carboxylic acid (102 mg, 88.3%) as an off-white solid: LR-MS for C6H5NO3S (M−H)+ at m/z=170.

Provenance & Evidence