HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[[6-(1H-Pyrazol-1-yl)-3-pyridinyl]methoxy]-1H-isoindole-1,3(2H)-dione → O-{[6-(1H-Pyrazol-1-yl)pyridin-3-yl]methyl}hydroxylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[[6-(1H-Pyrazol-1-yl)-3-pyridinyl]methoxy]-1H-isoindole-1,3(2H)-dione | HCID 16655947 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | O-{[6-(1H-Pyrazol-1-yl)pyridin-3-yl]methyl}hydroxylamine | HCID 10420028 | — |
Reaction Steps
A solution of the compound of Step 7d (32 g, 0.1 mol) in 100 ml of 2M NH3 in methanol was stirred at 50° C. for 4 hours. The reaction mixture was subsequently concentrated in vacuo and purified on silica gel to give the desired compound of formula (XI) (18.5 g, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07135573B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-9219ac1bd4324cb6bba7cfbb47bb59e5 |
| Source note | uspto-grants-2006_11 |