Sodium Hydroxide → HCID 9877694, compound

Participants

Reaction Steps

Reaction of N-(2-methyl-quinolin-4-yl)acetamide (136 mg, 0.679 mmol) using the general procedure for small scale hydrogenations (workup with NaOH in place of saturated NaHCO3) provided N-(2-methyl-5,6,7,8-tetrahydroquinolin-4-yl)acetamide (109 mg, 78%): 1H NMR δ 1.83–1.90 (m, 4H), 2.21 (s, 3H), 2.47 (s, 3H), 2.46–2.2.53 (m, 2H), 2.84–2.87 (m, 2H), 7.18 (br s, 1H), 7.82 (br s, 1H); 13C NMR δ 22.7, 22.8, 23.5, 24.6, 25.3, 33.1, 112.3, 117.3, 143.7, 156.4, 157.3, 169.0; MS m/z: 205 (M+H+).

Provenance & Evidence