Phthalimide → HCID 53485842, compound

Participants

Reaction Conditions

Reaction Steps

Into a reaction vessel were put phthalimide (2.00 g, 13.6 mol), (R)-epichlorohydrin (2.26 g, 24.5 mmol), anhydrous sodium carbonate (0.72 g, 6.80 mmol), tetra n-butylammonium hydrogensulfate (0.46 g, 1.36 mol) and isopropanol (13 ml) and the mixture was reacted at room temperature at 50° C. for 23 hours. And then to the residue was gradually added potassium tert-butoxide (1.83 g, 16.3 mmol) in isopropanol and the mixture is stirred at 20° C. for 1 hour. After the reaction, post-treatment was carried out to give crude (R)-glycidylphthalimide (2.21 g, yield 80%, optical purity 98% e.e.) as white crystals.

Provenance & Evidence