HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Iodobenzenesulphonyl chloride → N2-[(3-Iodophenyl)sulfonyl]glycinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Iodobenzenesulphonyl chloride | HCID 39766 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Glycinamide hydrochloride | HCID 2723639 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N2-[(3-Iodophenyl)sulfonyl]glycinamide | HCID 21895595 | 42.9% |
Reaction Steps
(3-Iodophenyl)sulphonyl chloride (0.303 g) was stirred with glycinamide hydrochloride (0.122 g) and diisopropylethylamine (0.3 ml) in DMF (4 ml) at 21° for 24 h. The mixture was evaporated to dryness and applied to a silica Bond Elut Cartridge (10 g). The cartridge was eluted with CH2Cl2, Et2O and EtOAc. This gave the title compound (0.146 g), LCMS RT=2.36 min, ES+ve 341 (MH)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07135600B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-3d0845533be24f6daf53f50064bfd17a |
| Source note | uspto-grants-2006_11 |