HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 720861Generated: October 27, 2026
Sodium Azide → 2-Azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone
https://huagongshe.com/reaction/720861
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)- | HCID 11150315 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone | HCID 11402365 | 86.7% |
Reaction Steps
2-Bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone (Glaxo DE 3513885, 1985) (52 g) in DMF (300 ml) was treated with sodium azide (12.24 g) and the mixture was stirred for 2 h at 20° C. The reaction mixture was diluted with ethyl acetate and washed with water and dried (MgSO4). The solvent was removed under reduced pressure to give the title compound (39.11 g). TSP+ve 248(MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07135600B2 |
|---|
| Source dataset | uspto-grants-2006_11 |
|---|
| ORD ID | ord-e709778a967a48198f1ccd63ef7609b8 |
|---|
| Source note | uspto-grants-2006_11 |
|---|
