HCID 69455082, compound → HCID 69452388, compound

HRID 720864Notes

Reaction equation

HRID 720864 reaction equation
[CH3:1][C:2]1([CH3:49])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C@@H:12]([OH:48])[CH2:13][NH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][C:24]#[C:25][C:26]3[CH:27]=[C:28]([S:32]([N:35]([CH2:40][O:41][CH2:42][CH2:43][Si:44]([CH3:47])([CH3:46])[CH3:45])[CH2:36][C:37]([NH2:39])=[O:38])(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=3)=[CH:11][C:5]=2[CH2:4][O:3]1>C(O)C.[Pt]=O>[CH3:1][C:2]1([CH3:49])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C@@H:12]([OH:48])[CH2:13][NH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]3[CH:27]=[C:28]([S:32]([N:35]([CH2:40][O:41][CH2:42][CH2:43][Si:44]([CH3:47])([CH3:46])[CH3:45])[CH2:36][C:37]([NH2:39])=[O:38])(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=3)=[CH:11][C:5]=2[CH2:4][O:3]1

Participants

4

Reactant 1

HCID 69455082HCID 69455082, compound

Product 1

HCID 69452388HCID 69452388, compoundYield 100.5%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

N2-[(3-{4-[(6-{[(2R)-2-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]but-1-ynyl}phenyl)sulfonyl]-N2-{[2-(trimethylsilyl)ethoxy]methyl}glycinamide (0.09 g) was stirred with platinum oxide (0.023 g) in ethanol (20 ml) under hydrogen for 3.5 h. The catalyst was filtered off with the aid of celite and the filter cake was leached with ethanol. The combined filtrates were evaporated to give the title compound (0.091 g) LCMS RT=3.10 min.

Workup

  1. filtrationThe catalyst was filtered off with the aid of celite
  2. customThe combined filtrates were evaporated

Sources & evidence

ORD record
ord-a1710b4fb3db424190186856eab9fe34
Source dataset
uspto-grants-2006_11
Patent number
US07135600B2

Reaction notes

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