HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl nipecotate → HCID 68575353, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl nipecotate | HCID 98969 | — |
| Reactant | (R)-5-(Oxiran-2-ylmethoxy)quinoline | HCID 11735808 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68575353 | HCID 68575353 | — |
Reaction Steps
Piperidine-3-carboxylic acid ethyl ester (43) (1.0 g; 6.36 mmol) and (R)-5-oxiranylmethoxy-quinoline (2) (1.28 g; 6.36 mmol) are combined in 10 mL of absolute ethanol. The mixture is heated at reflux for 16 hours. After cooling to ambient temperature, the solution is concentrated in vacuo at 40° C. The residue is chromatographed on silica gel (1:1 acetone:hexanes) affording the desired product (44) as an oil. ESMS:MH+ 359
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07135483B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-862efd50f1e04dddbaae148c5d536361 |
| Source note | uspto-grants-2006_11 |