反应详情

A solution of N-acetyl-colchinol (300 mg, 0.84 mmol), (J. Cech F. Santacy Collect. Czech Comm 1949, 4, 532–539), in pyridine (5 ml) was treated with 4-piperidinopiperidine carbamoyl chloride (346 mg, 1.5 mmol), (K. H. Henegar et al. J. Org. Chem., 1997, 62, 6588–6597) and the solution heated at reflux for 1 hour. The cooled mixture was filtered and the filtrate concentrated under reduced pressure. The residue was purified on silica gel eluting with methanol to give the title compound (180 mg) as a white solid.

1. temperaturethe solution heated
2. temperatureat reflux for 1 hour
3. filtrationThe cooled mixture was filtered
4. concentrationthe filtrate concentrated under reduced pressure
5. customThe residue was purified on silica gel eluting with methanol