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HRID720939

反应详情

EQUATION

反应方程式

HRID 720939 的结构方程式

REACTANTS

反应物

2
结构：CN1CCN(CCCO)CC1
HCID79208

3-(4-Methyl-1-piperazine)propan-1-ol

C8H18N2O

结构：COc1cc2c(c(OC)c1OC)-c1ccc(O)cc1C(NC(C)=O)CC2
HCID97865

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc2c(c(OC)c1OC)-c1ccc(OCCCN3CCN(C)CC3)cc1[C@@H](NC(C)=O)CC2
HCID9848717

未命名化合物

收率 22%

PROCEDURE

实验过程

Using an analogous procedure to that described for Example 7, N-acetyl-colchicinol was reacted with 4-(3-hydroxypropyl)-1-methylpiperazine to give N-[(5S)-3-(3-(4-methylpiperazin-1-yl)propoxy)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide.