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HRID720943

反应详情

EQUATION

反应方程式

HRID 720943 的结构方程式

REACTANTS

反应物

2
结构：C1COCCN1
HCID8083

Morpholine

C4H9NO

结构：COc1cc2c(c(OC)c1OC)-c1ccc(OC(=O)CCNC(=O)[C@@H](CCCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)cc1[C@@H](NC(C)=O)CC2
HCID69586384

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc2c(c(OC)c1OC)-c1ccc(OCC(O)CN3CCOCC3)cc1[C@@H](NC(C)=O)CC2
HCID9913914

未命名化合物

收率 55%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of N-[(5S)-3-(2,3-epoxypropoxy)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide (1) (0.092 g; 0.22 mmol) and morpholine (40 μl; 0.44 mmol) in methanol was heated at reflux for 4 hours. After evaporation to dryness the residue was purified by flash chromatography eluting with dichloromethane/ethanol (90/10) to give N-[(5S)-3-(2-hydroxy-3-morpholinopropoxy)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide as a yellow foam.

WORKUP

后处理

  1. temperatureat reflux for 4 hours
  2. customAfter evaporation to dryness the residue
  3. customwas purified by flash chromatography
  4. washeluting with dichloromethane/ethanol (90/10)