Morpholine → HCID 58658584, compound

HRID 720946Notes

Reaction equation

Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([O:11][C:12]2[CH:13]=[CH:14][C:15]3[C:21]4[C:22]([O:30][CH3:31])=[C:23]([O:28][CH3:29])[C:24]([O:26][CH3:27])=[CH:25][C:20]=4[CH2:19][CH2:18][C@H:17]([NH:32][C:33](=[O:35])[CH3:34])[C:16]=3[CH:36]=2)=[O:10])=[CH:5][CH:4]=1.[NH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1>>[O:40]1[CH2:41][CH2:42][N:37]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]([O:11][C:12]3[CH:13]=[CH:14][C:15]4[C:21]5[C:22]([O:30][CH3:31])=[C:23]([O:28][CH3:29])[C:24]([O:26][CH3:27])=[CH:25][C:20]=5[CH2:19][CH2:18][C@H:17]([NH:32][C:33](=[O:35])[CH3:34])[C:16]=4[CH:36]=3)=[O:10])=[CH:5][CH:4]=2)[CH2:38][CH2:39]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 58658596HCID 58658596, compound

Product 1

HCID 58658584HCID 58658584, compoundYield 86%

Procedure

Using an analogous procedure to that described for Example 16, N-[(5S)-3-(4-chloromethylphenylcarbonyloxy)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide was reacted with morpholine to give N-[(5S)-3-(4-{morpholinomethyl}phenylcarbonyloxy)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide.

Sources & evidence

ORD record: ord-b2e29ce33ae74fde8ccc6f5bd36e9d18
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07135502B1

Reaction notes

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