HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → Z-Gly-OSu
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate | HCID 9857522 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Z-Gly-OSu | HCID 76177 | 92% |
Reaction Steps
Z-Gly-OH (1.0 g, 4.78 mmol) was added THF (10 ml), DIEA (0.98 ml, 5.74 mmol), and TSTU (1.7 g, 5.74 mmol) and the resulting mixture was stirred at room temperature for 2 hours. AcOEt (100 ml) was added and the mixture was washed with 0.2N hydrochloric acid (100 ml) and water (2×100 ml). The organic phase was dried (Na2SO4) and concentrated in vacuo to afford 1.34 g (92%) of Z-Gly-OSu as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828923B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-f8eb6631e7f541dd9486b8d1a88e8574 |
| Source note | uspto-grants-2014_09 |