Nitric Acid → HCID 21890140, compound

Participants

Reaction Conditions

Reaction Steps

Nitric acid (0.5 ml) was added to 6,7-dimethoxy-4-(4-{[2-(3-methoxyphenoxy)ethyl]sulfanyl}phenoxy)quinoline (20 mg), and the mixture was stirred at 0° C. for 30 min. A saturated aqueous sodium hydrogencarbonate solution was added to the reaction solution, and the mixture was extracted with chloroform, followed by washing with saturated brine. The extract was then dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure. The residue was purified by thin-layer chromatography using chloroform/methanol for development to give the title compound (14 mg, yield 60%).

Provenance & Evidence