Ethanol → N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(4-nitrobenzoyl)thiourea

Participants

Reaction Steps

4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (50 mg) was dissolved in toluene (5 ml) and ethanol (1 ml) to prepare a solution. Commercially available 4-nitro-1-benzenecarbonyl isothiocyanate (30 mg) was then added to the solution, and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (80 mg, yield 94%).

Provenance & Evidence