Toluene → HCID 21890653, compound

HRID 721800Notes

Reaction equation

HRID 721800 reaction equation
C1(CC(Cl)=O)C=CC=CC=1.[C:11]1([CH2:17][C:18]([N:20]=[C:21]=[S:22])=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH3:23][O:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][C:34]=1[O:35][CH3:36])[N:31]=[CH:30][CH:29]=[C:28]2[O:37][C:38]1[CH:44]=[CH:43][C:41]([NH2:42])=[C:40]([F:45])[CH:39]=1.C1(C)C=CC=CC=1>C(O)C>[C:11]1([CH2:17][C:18]([N:20]=[C:21]=[S:22])=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH3:23][O:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][C:34]=1[O:35][CH3:36])[N:31]=[CH:30][CH:29]=[C:28]2[O:37][C:38]1[CH:44]=[CH:43][C:41]([NH:42][C:21]([NH:20][C:18](=[O:19])[CH2:17][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[S:22])=[C:40]([F:45])[CH:39]=1

Participants

7

Reactant 4

HCID 1140TolueneHCID 7679Phenylacetyl chlorideHCID 113014704-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluoroanilineHCID 12454157Phenylacetyl isothiocyanate

Product 2

HCID 12454157Phenylacetyl isothiocyanateHCID 21890653HCID 21890653, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

2-Phenylethanoyl isothiocyanate was prepared using commercially available 2-phenylethanoyl chloride (80 mg) as a starting compound according to the description of the literature. 2-Phenylethanoyl isothiocyanate was dissolved in ethanol (1 ml) to prepare a solution. 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluoroaniline (50 mg), toluene (5 ml), and ethanol (1 ml) were added to the solution, and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (65 mg, yield 83%).

Workup

  1. customto prepare a solution
  2. concentrationThe reaction solution was concentrated
  3. customthe residue was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-44f662cab6c1475a9caa10bedee5f9bc
Source dataset
uspto-grants-2006_11
Patent number
US07135466B2

Reaction notes

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