反应详情

This compound was prepared in an analogous fashion to (S)-4-(5-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-3-methylmorpholine, using (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane hydrochloride salt as the starting material. 1H NMR (CDCl3, 500 MHz) δ ppm 7.96 (s, 1H), 5.15 (s, 1H), 4.76 (s, 1H), 4.20 (s, 3H), 4.13 (d, J=8.1 Hz, 1H), 3.97 (ddd, J=7.0 Hz, 4.7 Hz, 1.5 Hz, 2H), 3.69 (d, J=9.5 Hz, 1H), 2.09 to 1.94 (m, 2H); LC-MS m/z (method A)=266.1 [M+H]+, RT=1.37 min.