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Potassium Carbonate → Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Fluoro-2-nitrotoluene | HCID 94956 | — |
| 反応物 | 3-(Dimethylamino)pyrrolidine | HCID 2758519 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine | HCID 68977058 | — |
反応手順
A mixture of 4-fluoro-2-methyl-1-nitrobenzene (13.6 g), dimethylpyrrolidin-3-ylamine (10.0 g), potassium carbonate (12 g) and DMF (100 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way; MS (ESI): 250 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828991B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-0875dc4f41854179839123d1593d5957 |
| 出典メモ | uspto-grants-2014_09 |