HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-(4-Chlorophenyl)-4-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178517488 | HCID 178517488 | — |
| Product | 2-(4-Chlorophenyl)-4-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine | HCID 11161400 | — |
Reaction Steps
8.0 g of 2-(4-chlorophenyl)-4-hydroxy-6,7-dihydro-5H-cyclopenta[d]pyrimidine are heated to 100° C in 10 ml of phosphorus oxychloride. After 3 hours, the cooled solution was cautiously poured onto ice water. The crystalline product was filtered off with suction, washed well with water and dried in vacuo at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138398B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-ed0ea368e777462c95fdaa9bb43507b3 |
| Source note | uspto-grants-2006_11 |