5-Methylpyridine-2,3-diamine → HCID 178493173, compound

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Reaction Steps

Similarly to Example 1, 0.428 g of 3-(4methoxypyridin-2-yl)propionic acid (starting material A1), 0.26 g of 2,3-diamino-5-methylpyridine (Lappin et al., J. Amer. Chem Soc. 72, 2806 (1950) and 8 g of PPA (4 hours at 140° C.) give 0.25 g of the title compound of m.p. 150–152° C. (crystallized from ethyl acetate). The mass spectrum shows the molecular peaks MH+ and 2MNa+ at 269.3 and 559.1 Da.

Provenance & Evidence