Methyl 3-(4-methoxypyridin-2-yl)acrylate → Methyl 3-(4-methoxypyridin-2-yl)propanoate

Participants

Reaction Steps

43.1 g of methyl 3-(4-methoxypyridin-2-yl)acrylate (starting material A3) in 600 ml of methanol are hydrogenated over 3.0 g of 10% strength Pd/C until the starting material has disappeared (TLC). The catalyst is filtered off, and the mixture is then concentrated and dried under high vacuum. This gives 41.95 g of the title compound as a light-yellow oil. The mass spectrum shows the molecular peak MH+ at 196 Da.

Provenance & Evidence