2-Amino-3-nitro-5-phenylpyridine → HCID 21882715, compound

Participants

Reaction Steps

0.46 g of 2-amino-3-nitro-5-phenylpyridine (starting material C2) dissolved in 50 ml methanol are hydrogenated over 0.05 g of 10% strength Pd/C until no starting material is detectable by TLC. After filtration, the solvent is evaporated and the residue is chromatographed over silica gel (dichloromethane/methanol 20:1+1% triethylamine). Concentration of the pure fractions and drying in vacuo gives 0.38 g of the title compound as a brownish oil. The mass spectrum shows the molecular peak MH+ at 186.2 Da.

Provenance & Evidence