反应详情

0.46 g of 2-amino-3-nitro-5-(2-methylpropyl)pyridine (starting material D2) dissolved in 20 ml of methanol are hydrogenated over 0.05 g of 10% strength Pd/C until no starting material is detectable by TLC. After filtration, the solvent is evaporated and the residue is chromatographed over silica gel (dichloromethane/methanol 25:1). Concentration of the pure fractions and drying in vacuo gives 0.34 g of the title compound as an oil. The mass spectrum shows the molecular peak MH+ at 166.2 Da.

1. filtrationAfter filtration
2. customthe solvent is evaporated
3. customthe residue is chromatographed over silica gel (dichloromethane/methanol 25:1)
4. customConcentration of the pure fractions and drying in vacuo