Methane → HCID 21882732, compound

Participants

Reaction Steps

0.051 g of ferric chloride and 0.085 g of activated charcoal are added to a suspension of 0.35 g of 2-amino-5-(3,4-dichlorphenyl)-3-nitropyridine (starting material G2) in 10 ml of methanol and the mixture is heated under reflux. 0.270 ml of hydrazine hydrate are added slowly and reflux is continued for 12 hours. After cooling the mixture is filtered and the filtrate is evaporated. The residue is partitioned between sodium-EDTA-solution (0.25M; pH 9–10) and dichloromethane. The organic phase is evaporated to give 0.20 g of the title compound as a yellowish solid of m.p. 202–204° C. The mass spectrum shows the molecular peak MH+ at 254.2 Da.

Provenance & Evidence